By continuing to browse this site you are agreeing to our use of cookies. Alcohol with zosyn piperacillin and tazobactam, piperacillin and tazobactam decreases the effectiveness of the antibiotic and increase its side effects. Most often zosyn piperacillin and tazobactam is given in a hospital setting, and the likelyhood of consuming alcohol is almost nil in the hospital. Zosyn piperacillin and tazobactam for injection, for intravenous use. Primary endpoints were icuccu mortality at discharge and length of stay. It works by killing the bacteria and preventing their growth.
Protein binding of the tazobactam metabolite is negligible. Drug shortages are a significant obstacle in providing excellent patient care, especially when shortages impact workhorse agents such as piperacillintazobactam. Zosyn piperacillin and tazobactam for injection, usp contains a total of 2. Apr 01, 2019 piperacillin and tazobactam side effects. Piperacillin plasma concentrations, following a 30minute infusion of zosyn piperacillin and tazobactam for injection, usp, were similar to those attained when equivalent doses of piperacillin were administered alone, with mean peak plasma concentrations of approximately 4. For pediatric patients between 2months and 9 months of age, the recommended zosyn dosage based on pharmacokinetic modeling, is 80mg piperacillin10mg tazobactam per kilogram of body weight. Mylan manufactures piperacillin and tazobactam for injection, usp zosyn in strengths of 3 g375 mg. Piperacillin and tazobactam for injection wg critical care. Piperacillin and tazobactam combination is an antibiotic that belongs to the group of medicines known as penicillins and betalactamase inhibitors. For complete ordering information, please contact your local pharmaceutical distributor. Zosyn piperacillin and tazobactam for injection, usp pfizer. Monitor kidney function in patients for pediatric patients 2 to 9 months of age, the recommended dosage is 80 mg piperacillin 10 mg tazobactam per kilogram of body. Jul 10, 2019 the usual daily dose of piperacillin and tazobactam for injection for adults is 3. The betalactam ring is hydrolyzed to form the pharmacologically inactive tazobactam metabolite m1.
Find patient medical information for piperacillintazobactamdextrose iso intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and. Infusion to reduce the development of drugresistant bacteria and maintain the effectiveness of zosyn. Zosyn piperacillin and tazobactam for injection, usp the. Data was collected for patients that received piperacillintazobactam in the icuccu from december 19th, 2010 through march 19th, 2011 for traditional infusion and from december 19th, 2011 through march 19th, 2012 for extended infusion.
For more information, please call 844 9897284 or visit eligible patients can register for valuable savings offers for nearly 40 brand name medications. Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling. Each vial contains nafcillin sodium, as the monohydrate equivalent to 10 grams of nafcillin. Zosyn piperacillin and tazobactam for injection, usp. Piperacillin and tazobactam is a combination penicillin antibiotic that is used to treat many different infections caused by bacteria, such as stomach infections, skin infections, pneumonia, and severe vaginal infections this medication is sometimes given together with other antibiotics piperacillin and tazobactam may also be used for purposes not listed in this. Drug shortages are a significant obstacle in providing excellent patient care, especially when shortages impact workhorse agents such as piperacillin tazobactam. Piperacillin and tazobactam fda prescribing information.
Piperacillin and tazobactam for injection is a combination product consisting of a penicillinclass antibacterial, piperacillin, and a. Dosing of piperacillintazobactam in a morbidly obese. The protein binding of either piperacillin or tazobactam is unaffected by the presence of the other compound. Instruction for inserting the needle into the rubber stopper. Minimum inhibitory concentrations mcgml disk diffusion zone diameter in mm pathogen. Auromedics pharma llc 279 princeton hightstown road east windsor, nj 08520. Both piperacillin and tazobactam are approximately 30% bound to plasma proteins. Piperacillin is an extendedspectrum penicillin antibiotic, but it can be destroyed by an enzyme produced by bacteria called beta lactamase.
Clinical pharmacology adults peak plasma concentrations of piperacillin and tazobactam are attained immediately after completion of an intravenous infusion of zosyn. Piperacillin and tazobactam for compound time f1 %1 tazobactam related 0. Piperacillin and tazobactam for injection, usp zosyn 3. Safety data sheet piperacillin and tazobactam for injection usp. Piperacillin and tazobactam intravenous route description. Easeofuse is provided by shatterproof springloaded cartridges, easytoread labeling and endofcartridge indicators. Piperacillin and tazobactam for injection should be adminis.
It may cause allergic reactions in individuals with a history of penicillin hypersensitivity or a history. Disk diffusion not only categorizes resistant, intermediate and sensitive organisms through quantitative results but also provides a visual indication of the following. Piperacillin and tazobactam for injection is an injectable antibacterial combination, p oduct consisting. To reduce the development of drugresistant bacteria and maintain the effectiveness of zosyn and other antibacterial drugs, zosyn should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Each nafcillin for injection, usp pharmacy bulk package is supplied as a dry powder in bottles containing nafcillin sodium and is intended for intravenous use only. It is usually given every 6 hours, but children 9 months of age and older may receive it every 8 hours. Proteinbinding of the tazobactam metabolite is negligible. Zosyn piperacillin and tazobactam for injection fda. Piperacillin and tazobactam injection comes as a powder to be mixed with liquid and injected intravenously into a vein. How does alcohol affect zosyn piperacillin and tazobactam. Pfizer rxpathways connects eligible patients, regardless of their insurance status, to a range of assistance programs that offer insurance support, copay help, and medicines for free or at a savings. Comprehensive guidance for antibiotic dosing in obese adults. Piperacillin and tazobactam for injection, usp parenteral combination is a white to offwhite sterile, cryodesiccated powder consisting of piperacillin and tazobactam as their sodium salts packaged in glass vials. Ceftolozanetazobactam zerbaxa national drug monograph. Nlh1480001002ib017 page 48 like all medicines, this medicine can cause side effects, although not everybody gets them.
Piperacillin sodiumtazobactam sodium powder for injection. Piperacillin and tazobactam for injection is a drug used to treat bacterial infections. Zosyn piperacillin, tazobactam other pfizer medical. The product does not contain excipients or preservatives. While piperacillin sodiumtazobactam sodium powder for injection is indicated only for the conditions listed above, infections caused by piperacillin susceptible organisms are also amenable to piperacillin sodiumtazobactam sodium powder for injection treatment due to its piperacillin content. Zosyn piperacillin, tazobactam dosage and administration. Piperacillintazobactam as an alternative antibiotic therapy. If you notice any of the following side effects, stop taking this medicine and contact your doctor, or. Mar 01, 2020 piperacillin and tazobactam for injection is a combination product consisting of a penicillinclass antibacterial, piperacillin, and a. Dosing for zerbaxa ceftolozane and tazobactam official site. Oxoid piperacillintazobactam antimicrobial susceptibility disks. The package insert states decreased efficacy seen in patients with a baseline creatinine clearance piperacillin and tazobactam, with broad spectrum activity against an extended range of bacterial species. Piperacillin, tazobactam, and desethyl piperacillin are also secreted into the bile.
Piperacillin 2 g as piperacillin sodium and tazobactam 0. Administration of amikacin or gentamicin in a single daily dose or in doses exceeding those stated above via ysite with piperacillin and tazobactam for injection has not been evaluated. See package insert for each aminoglycoside for complete dosage and administration instructions. Monitor kidney function in patients for pediatric patients 2 to 9 months of age, the recommended dosage is 80 mg piperacillin10 mg tazobactam per kilogram of body. This regimen may also be applicable to treat patients with other indicated infections when. Piperacillin and tazobactam for injection page 1 of 41. Zosyn piperacillin and tazobactam for injection, usp rx. Comprehensive guidance for antibiotic dosing in obese. The recommended dosage of zerbaxa for injection is 1. Dailymed piperacillin and tazobactam injection, powder. Information for the user piperacillintazobactam 4 g. Outcomes of an extendedinfusion piperacillintazobactam. Limited data suggests that coadministration of methotrexate and piperacillin may reduce the. Download leaflet view the patient leaflet in pdf format.
Zosyn piperacillintazobactam dose, indications, adverse. The length of treatment depends on your general health, the type of infection you have, and how well you respond to the. For pediatric patients between 2months and 9 months of age, the recommended zosyn dosage based on pharmacokinetic modeling, is 80mg piperacillin 10mg tazobactam per kilogram of body weight. The pk parameters in this morbidly obese patient were substantially different when compared with the product information. Piperacillin and tazobactam for injection, usp zosyn 3 g375. The usual total daily dose of piperacillin and tazobactam for injection for adults is 3.